| Ingredient | Amount | % DV% Daily Value — how much of the recommended daily intake one serving provides, based on a 2,000 calorie diet. 100% = full daily need. Values over 100% are common for water-soluble vitamins (B, C) and generally safe. Values over 200% are highlighted. |
|---|---|---|
| 5-MTHF | 900 mcg | 225% |
| Methylcobalamin | 600 mcg | 9167% |
| Niacinamide | 20 mg | 100% |
| Riboflavin 5-Phosphate | 2 mg | 100% |
| Magnesium Malate | 100 mg | 25% |
| Zinc Chelate | 40 mg | 73% |
| Vitamin C | 60 mg | 100% |
| Se Methionine | 1 mg | 71% |
| Pyridoxine Alpha-Ketoglutarate | 2.5 mg | 125% |
| Molybdenum Chelate | 15 mcg | 20% |
| Biotin | 200 mcg | 67% |
| Proprietary Methyl Blend | 765 mg | — |
| Proprietary Matrix Blend | 320 mg | — |
Other ingredients: Gelatin, Lactose, Leucine
This score evaluates label quality — dosage disclosure, transparency, cleanliness of inactive ingredients, and formula composition. It does not measure clinical efficacy, bioavailability, or third-party testing. Read full methodology
Same category, higher SupplementScore. Based on dosage transparency, label cleanliness, and formula quality.
The research summaries below are about the ingredients in general, drawn from published studies that often use different doses, forms, and populations than this product. A "strong" evidence rating for an ingredient does not mean this product will produce that effect — studied doses may be significantly higher or lower than what is contained here. Always verify doses against the Supplement Facts table above.
Supports immune cell function. Regular supplementation may modestly reduce cold duration, but does not prevent colds.
Potent water-soluble antioxidant that protects cells from oxidative damage.
Essential cofactor for enzymes involved in collagen production.
Limited evidence. May help in cases of biotin deficiency but most people get adequate amounts from diet.
Essential cofactor for carboxylases involved in gluconeogenesis, fatty acid synthesis, and amino acid catabolism.
Essential for red blood cell formation. Deficiency causes megaloblastic anemia, confirmed by decades of clinical evidence.
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Alternatives are selected from the same category (B Vitamins) with a higher overall score. This is not a recommendation — always verify ingredients and dosages match your needs.
Involved in myelin synthesis and nerve function. Adequate B12 status supports neurological health, particularly in older adults and vegans.
Cofactor in energy production pathways, but supplementation only helps if deficient.
May improve sleep quality, especially in older adults and those with low magnesium status.
60% of body magnesium is stored in bone. Essential for bone mineralization.
May reduce muscle cramps and support post-exercise recovery.
Zinc is a cofactor for over 300 enzymes involved in immune cell development and function. Supplementation may reduce duration of common cold symptoms, particularly as lozenges. Essential for maintaining immune barrier integrity.
Essential for skin integrity and wound repair processes.
Essential for red blood cell formation. Deficiency causes megaloblastic anemia, confirmed by decades of clinical evidence.
Involved in myelin synthesis and nerve function. Adequate B12 status supports neurological health, particularly in older adults and vegans.
Cofactor in energy production pathways, but supplementation only helps if deficient.
Adequate folate intake before and during early pregnancy reduces risk of neural tube defects. This is one of the most well-established findings in nutrition.
Essential cofactor for nucleotide synthesis and cell division.
Adequate folate intake before and during early pregnancy reduces risk of neural tube defects. This is one of the most well-established findings in nutrition.
Essential cofactor for nucleotide synthesis and cell division.
Involved in neurotransmitter synthesis including serotonin and dopamine.
Cofactor in the transsulfuration pathway, converting homocysteine to cysteine (separate from B12/folate remethylation pathway).
At pharmacological doses (1500-3000mg), niacin may improve HDL cholesterol. This effect is dose-dependent and not expected at typical supplement doses.
Essential coenzyme (NAD/NADP) in hundreds of metabolic reactions.
At 400mg/day (far above RDA of 1.3mg), riboflavin may reduce migraine frequency. Effect is dose-dependent and not expected at typical supplement doses.