This score evaluates label quality — dosage disclosure, transparency, cleanliness of inactive ingredients, and formula composition. It does not measure clinical efficacy, bioavailability, or third-party testing. Read full methodology
Same category, higher SupplementScore. Based on dosage transparency, label cleanliness, and formula quality.
The research summaries below are about the ingredients in general, drawn from published studies that often use different doses, forms, and populations than this product. A "strong" evidence rating for an ingredient does not mean this product will produce that effect — studied doses may be significantly higher or lower than what is contained here. Always verify doses against the Supplement Facts table above.
Primary structural component of bones. Adequate lifelong intake, combined with vitamin D, helps prevent osteoporosis — supported by extensive clinical evidence.
Essential for muscle contraction through calcium signaling.
At 400mg/day (far above RDA of 1.3mg), riboflavin may reduce migraine frequency. Effect is dose-dependent and not expected at typical supplement doses.
Limited evidence. May help in cases of biotin deficiency but most people get adequate amounts from diet.
Essential cofactor for carboxylases involved in gluconeogenesis, fatty acid synthesis, and amino acid catabolism.
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Alternatives are selected from the same category (Protein Supplements) with a higher overall score. This is not a recommendation — always verify ingredients and dosages match your needs.
Iron supplementation is used to address iron deficiency. Should be taken under medical supervision as excess iron can be harmful.
Iron is essential for oxygen transport and cellular energy production.
Essential for calcium absorption. Deficiency leads to rickets in children and osteomalacia in adults — a well-established causal relationship.
May reduce risk of respiratory infections. Active area of research.
Some association between low vitamin D levels and depression, but evidence is inconsistent.
Essential cofactor for pyruvate dehydrogenase and other enzymes in carbohydrate metabolism.
Protects polyunsaturated fatty acids in cell membranes from oxidation.
May help protect skin from UV damage when combined with vitamin C.
May improve sleep quality, especially in older adults and those with low magnesium status.
60% of body magnesium is stored in bone. Essential for bone mineralization.
May reduce muscle cramps and support post-exercise recovery.
Essential for red blood cell formation. Deficiency causes megaloblastic anemia, confirmed by decades of clinical evidence.
Involved in myelin synthesis and nerve function. Adequate B12 status supports neurological health, particularly in older adults and vegans.
Cofactor in energy production pathways, but supplementation only helps if deficient.
Primary structural component of bones. Adequate lifelong intake, combined with vitamin D, helps prevent osteoporosis — supported by extensive clinical evidence.
Essential for muscle contraction through calcium signaling.
May improve sleep quality, especially in older adults and those with low magnesium status.
60% of body magnesium is stored in bone. Essential for bone mineralization.
May reduce muscle cramps and support post-exercise recovery.
Protects polyunsaturated fatty acids in cell membranes from oxidation.
May help protect skin from UV damage when combined with vitamin C.
Essential for red blood cell formation. Deficiency causes megaloblastic anemia, confirmed by decades of clinical evidence.
Involved in myelin synthesis and nerve function. Adequate B12 status supports neurological health, particularly in older adults and vegans.
Cofactor in energy production pathways, but supplementation only helps if deficient.
Adequate folate intake before and during early pregnancy reduces risk of neural tube defects. This is one of the most well-established findings in nutrition.
Essential cofactor for nucleotide synthesis and cell division.
Involved in neurotransmitter synthesis including serotonin and dopamine.
Cofactor in the transsulfuration pathway, converting homocysteine to cysteine (separate from B12/folate remethylation pathway).
Essential for calcium absorption. Deficiency leads to rickets in children and osteomalacia in adults — a well-established causal relationship.
May reduce risk of respiratory infections. Active area of research.
Some association between low vitamin D levels and depression, but evidence is inconsistent.
At pharmacological doses (1500-3000mg), niacin may improve HDL cholesterol. This effect is dose-dependent and not expected at typical supplement doses.
Essential coenzyme (NAD/NADP) in hundreds of metabolic reactions.
No FDA warnings or recalls on file.