| Ingredient | Amount | % DV% Daily Value — how much of the recommended daily intake one serving provides, based on a 2,000 calorie diet. 100% = full daily need. Values over 100% are common for water-soluble vitamins (B, C) and generally safe. Values over 200% are highlighted. |
|---|---|---|
| SAMe | 500 mg | — |
| 5-HTP | 200 mg | — |
| L-Tryptophan | 1400 mg | — |
| Niacin | 70 mg | 350% |
| Vitamin B6 | 70 mg | 3500% |
| Folic Acid | 990 mcg | 250% |
| Vitamin B12 | 1600 mcg | 26670% |
Other ingredients: Stearic Acid, Dicalcium Phosphate, Microcrystalline Cellulose, Magnesium Stearate, Croscarmellose Sodium, Silicon Dioxide, Glyceryl Triacetate, Hydroxypropyl Methyl Cellulose Pthalate, Ethanol, Water, Titanium Dioxide
This score evaluates label quality — dosage disclosure, transparency, cleanliness of inactive ingredients, and formula composition. It does not measure clinical efficacy, bioavailability, or third-party testing. Read full methodology
Same category, higher SupplementScore. Based on dosage transparency, label cleanliness, and formula quality.
The research summaries below are about the ingredients in general, drawn from published studies that often use different doses, forms, and populations than this product. A "strong" evidence rating for an ingredient does not mean this product will produce that effect — studied doses may be significantly higher or lower than what is contained here. Always verify doses against the Supplement Facts table above.
Essential for red blood cell formation. Deficiency causes megaloblastic anemia, confirmed by decades of clinical evidence.
Involved in myelin synthesis and nerve function. Adequate B12 status supports neurological health, particularly in older adults and vegans.
Cofactor in energy production pathways, but supplementation only helps if deficient.
Involved in neurotransmitter synthesis including serotonin and dopamine. Cofactor for over 100 enzyme reactions.
B6 is a cofactor in the transsulfuration pathway, converting homocysteine to cysteine. This is a separate pathway from the B12/folate remethylation route.
At pharmacological doses (1500-3000mg), niacin may improve HDL cholesterol. This effect is dose-dependent and not expected at typical supplement doses.
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Alternatives are selected from the same category (B Vitamins) with a higher overall score. This is not a recommendation — always verify ingredients and dosages match your needs.
Essential coenzyme (NAD/NADP) in hundreds of metabolic reactions.
Adequate folate intake before and during early pregnancy reduces risk of neural tube defects. This is one of the most well-established findings in nutrition.
Essential cofactor for nucleotide synthesis and cell division.
Adequate folate intake before and during early pregnancy reduces risk of neural tube defects. This is one of the most well-established findings in nutrition.
Essential cofactor for nucleotide synthesis and cell division.