KSM-66 Ashwagandha root extract

Also known as: withania somnifera, indian ginseng, ksm-66, sensoril

Adaptogenic herb (Withania somnifera) used in Ayurvedic medicine for thousands of years. Helps body manage stress by modulating cortisol and supporting adrenal function.

34ProductsNumber of supplements in our database that contain this ingredient.

3Health ClaimsNumber of researched health benefits associated with this ingredient, rated by evidence strength (strong/moderate/weak).

4Side EffectsNumber of documented side effects from clinical literature and adverse event reports.

Health Claims & Evidence

strongReduces stress and anxiety

Multiple RCTs show cortisol reduction and improved stress/anxiety scores, primarily with standardized extracts (KSM-66, Sensoril) at 300-600mg/day.

5 studies on PubMed

Related studies:Automatically retrieved from PubMed based on keyword matching. Some may not directly address the specific claim above.Can Ashwagandha Benefit the Endocrine System?-A Review.Int J Mol Sci (2023) · PMID 38003702 A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study.Medicine (Baltimore) (2023) · PMID 37832082 The benefits of ashwagandha (Withania somnifera) supplements on brain function and sports performance.Front Nutr (2024) · PMID 39155932

moderateMay improve testosterone

Limited evidence for testosterone effects, primarily in stressed or subfertile men using KSM-66 extract. Results in healthy men are inconsistent.

3 studies on PubMed

Related studies:Automatically retrieved from PubMed based on keyword matching. Some may not directly address the specific claim above.Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial.J Psychopharmacol (2023) · PMID 37740662 Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial.J Int Soc Sports Nutr (2015) · PMID 26609282 Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study.J Obstet Gynaecol Res (2021) · PMID 34553463

moderateSupports athletic performance

May improve VO2 max, strength, and recovery. Typically studied at 300-600mg/day of standardized root extract (KSM-66 or equivalent).

5 studies on PubMed

Related studies:Automatically retrieved from PubMed based on keyword matching. Some may not directly address the specific claim above.The benefits of ashwagandha (Withania somnifera) supplements on brain function and sports performance.Front Nutr (2024) · PMID 39155932 Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial.J Int Soc Sports Nutr (2015) · PMID 26609282 A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults.J Ethnopharmacol (2021) · PMID 33600918

Known Side Effects

drowsiness
upset stomach
thyroid hormone changes
not safe during pregnancy

Drug Interactions

thyroid medications
immunosuppressants
sedatives
blood sugar medications

Always consult your healthcare provider before combining supplements with medications.

Health Claims & Evidence

Known Side Effects

Drug Interactions

Products Containing KSM-66 Ashwagandha root extract (34)