Folic Acid, Natural

Also known as: folic acid, methylfolate, 5-mthf, folacin, l-methylfolate

B vitamin critical for DNA synthesis and cell division. Especially important during pregnancy to prevent neural tube defects. Folic acid is the synthetic form.

400mcg DFERDARecommended Dietary Allowance — the daily intake sufficient for 97-98% of healthy adults. Set by the National Institutes of Health.

1000mcgUpper LimitTolerable Upper Intake Level (UL) — the maximum daily dose unlikely to cause adverse health effects. Exceeding this consistently may increase toxicity risk.

2ProductsNumber of supplements in our database that contain this ingredient.

2Health ClaimsNumber of researched health benefits associated with this ingredient, rated by evidence strength (strong/moderate/weak).

2Side EffectsNumber of documented side effects from clinical literature and adverse event reports.

Health Claims & Evidence

strongPrevents neural tube defects

Adequate folate intake before and during early pregnancy reduces risk of neural tube defects. This is one of the most well-established findings in nutrition.

63 studies on PubMed

Related studies:Automatically retrieved from PubMed based on keyword matching. Some may not directly address the specific claim above.Spina bifida.Nat Rev Dis Primers (2015) · PMID 27189655 Folate, folic acid and 5-methyltetrahydrofolate are not the same thing.Xenobiotica (2014) · PMID 24494987 Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.Cochrane Database Syst Rev (2022) · PMID 36321557

strongSupports DNA synthesis

Essential cofactor for nucleotide synthesis and cell division.

32 studies on PubMed

Related studies:Automatically retrieved from PubMed based on keyword matching. Some may not directly address the specific claim above.The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.Medicine (Baltimore) (2024) · PMID 38728462 Uncovering the Hidden Dangers and Molecular Mechanisms of Excess Folate: A Narrative Review.Nutrients (2023) · PMID 37960352 NIR2-Folate. (2004) · PMID 20641765

Known Side Effects

may mask B12 deficiency
rare allergic reactions

Drug Interactions

methotrexate
anti-epileptic drugs
sulfasalazine

Always consult your healthcare provider before combining supplements with medications.

Products Containing Folic Acid, Natural (2)

Wholesome WellnessWhole Food Multi-Vitamin for Men

74 2

Wholesome WellnessWhole Food Multivitamin for Women