10 Best Liver & Detox Supplements

By The Supplement Ratings editorial team1,862 products analyzed

Liver and detox products are dominated by milk thistle, and by "cleanse" formulas that list a dozen herbs under one blend weight. A well-labeled milk thistle states its silymarin content; many products do not.

We ranked milk thistle, silymarin, TUDCA, artichoke and liver-support formulas sold on iHerb by label quality.

Our top picks

Metabolic MaintenanceMetabolic Detox

89/100

Scores 35/35 for dosage transparency, 25/25 for a clean formula, 21/25 for label completeness. 4 ingredients disclosed with amounts.

capsule · 30 servings · $1.59/servingBuy on iHerb$47.78

Aerobic LifeLiver Fend

88/100

Scores 31/35 for dosage transparency, 25/25 for a clean formula, 24/25 for label completeness. 6 ingredients disclosed with amounts.

capsule · 30 servings · $0.90/servingBuy on iHerb$26.95

EmeraldLiver Health

86/100

Scores 30/35 for dosage transparency, 25/25 for a clean formula, 20/25 for label completeness. 8 ingredients disclosed with amounts.

capsule · 30 servings · $1.20/servingBuy on iHerb$35.87

How we ranked them

Every product is scored 0–100 from its label data in the NIH Dietary Supplement Label Database: dosage transparency (35 points - are amounts stated per ingredient, or hidden in a proprietary blend?), label completeness (25), formulation cleanliness (25 - fillers, dyes, titanium dioxide and other non-active ingredients) and ingredient profile (15). The Top 10 admits only products scoring 60 or higher; among those, products with a verified retail listing are shown first so the list is one you can act on. No brand can pay to be included or moved up.

Forms and dosage

Milk thistle extract: Standardized to 70–80% silymarin; the label should state the percentage.
Silymarin phytosome: Bound to phospholipids; dosed lower than plain extract.
TUDCA: A bile acid; commonly 250–500 mg per serving.
"Detox" and cleanse blends: Often many herbs and laxatives under one total weight.

How much to take

Studies of milk thistle have commonly used about 420 mg per day of extract standardized to 70–80% silymarin. Doses for other ingredients are product-specific.

Frequently Asked Questions

How do I compare milk thistle supplements?

By silymarin content: extract amount times the standardization percentage. That is the figure our ranking rewards for being on the label.

Do detox supplements work?

Our score measures label quality, not outcomes. Many cleanse products contain laxatives; check the label.

How are liver & detox supplements ranked?

Products are ranked by SupplementScore, which evaluates label quality across four categories: dosage transparency (35 pts), label completeness (25 pts), formulation cleanliness (25 pts), and ingredient profile (15 pts). The score is based on data from the NIH Dietary Supplement Label Database, not marketing claims.

Does a higher score mean the supplement is more effective?

No. The SupplementScore measures label quality, how transparent, clean, and well-documented a product is. It does not measure clinical efficacy, bioavailability, or third-party testing. A higher score means better label practices, not guaranteed results.

How many liver & detox supplements were analyzed?

We analyzed 1,862 liver & detox products from the NIH DSLD database, which contains label data for over 116,000 dietary supplements sold in the United States.